4月28日火曜1５時よりドイツ・Johannes Gutenberg University Mainz Axel Müller教授による2015多元研生命有機・物理化学セミナー02を 実施致します。皆様、ご多忙なこととは存じますが、是非多数のご参加をお願い致します。
Prof. Axel Müller (Institute of Organic Chemistry, Johannes Gutenberg University Mainz) 講演会
主催/ Organizer： 東北大学 原子・分子材料科学高等研究機構（AIMR）、多元物質科学研究所（IMRAM）
共催/Co-organizer： 物質デバイス領域共同研究拠点、ナノマクロ物質・デバイス・システム創製アライアンス 他
日時/ Date： 2014年4月28日(火)15時〜16時30分/ from 3pm to 4:30pm on April 28(Tue)
片平北門会館2階エスパス/ ESPASS, Katahira Kitamon Commons
金属材料研究所2号館1階金研講堂/ Tohoku Univ. IMR Auditorium
題目/ Title： Self-Organized Multicompartment Nanostructures Inspired by the Cell: Basic Findings and Biomedical Applications
講師/ Speaker： Prof. Axel Müller (Institute of Organic Chemistry, Johannes Gutenberg University Mainz)
概要/ Abstract： Compartmentalization is the most important feature in living organisms, best seen in plant or animal cells, where different compartments have different functions. We aim at mimicking nature in synthesizing multicompartment micelles, which simultaneously can host different payloads, such as drugs or magnetic or fluorescent nanoparticles. The self-assembly of triblock terpolymers (also known as ABC triblock copolymers) in solution and in the bulk are ideally suited for such a task. A typical example is polystyrene-block-polybutadiene-block-poly(methyl methacrylate) (SBM). Compartmentalization can occur either in the corona or in the core. We have prepared corona-compartmentalized nanoparticles (Janus spheres, cylinders, or disks) by crosslinking domains in the bulk nanostructures of triblock terpolymers. These Janus micelles have superior properties as interfacial agents, as stabilizers in emulsion polymerization, as compatibilizers of polymer blends, or for the solubilization of carbon nanotubes. Here we present a flexible route for the hierarchical, guided self-assembly of triblock terpolymers into multicompartment micelles (MCMs) of different shapes and sizes, simply by choosing the right solvent conditions and solvent sequences. These MCMs can have spherical shapes, like hamburgers, clovers, or footballs. However, by choosing the right terpolymers composition we can also trigger the shapes in a way that they reversibly form worm-like structures with alternating compartments of, e.g. polystyrene and polybutadiene, with a corona of PMMA. The different compartments can be loaded with various nanoparticles or drugs. Co-assembly of AB- and ABA-style building blocks for MCMs leads to new, complex linear structures at a further level of hierarchy, resembling caterpillars, and allowing control of the chain length from less than 1 μm up to 30 μm. A new triblock terpolymer, polybutadiene-block-poly(quaternized 2-vinylpyridene)-block- poly(methacrylic acid) (PVqMAA) forms multicompartment micelles in water with patches of an interpolyelectrolyte complex (IPEC) between the shorter cationic and a part of the longer anionic block. Interaction of the PMAA corona of these micelles with block copolymer of a polycation and poly(ethylene oxide) leads to complex core-shell-shell-corona micelles or even “paddle-wheel” structures. These structures are used host nanoparticles or drugs.
Axel H. E. Müller obtained his Ph.D. in 1977 from the Johannes Gutenberg University in Mainz, working with Prof. G. V. Schulz. From 1999-2012 he was full professor and chair of Macromolecular Chemistry at the University of Bayreuth. In October 2012 he retired from Bayreuth and moved back to Mainz University to continue research as a Fellow of the Gutenberg Research College. His research interest focuses on the design of complex polymer and hybrid structures by controlled/living polymerization techniques and on self-organized nanostructures obtained from these polymers in bulk and solution. Structures of interest include multicompartment micelles, soft Janus particles, cylindrical core-shell brushes, and hybrids of polymers and inorganic or biological materials. He has published over 450 research papers and edited various books. His papers have been cited more than 15,000 times. He is Senior Editor of the journal Polymer.
問合/Contact： 栗原和枝教授（WPI-AIMR/多元研）：Prof. Kazue KURIHARA (email@example.com)
和田健彦教授（多元研/IMRAM）：Prof. Takehiko WADA（firstname.lastname@example.org）
多元研世話人：和田健彦（E-Mail ：email@example.com；EX. 5608）